Question: Is RNA quality assessment (either by RIN or DV200) important for Xenium?
Answer: As a probe based assay, Xenium is robust to RNA degradation often seen in FFPE blocks. We have not seen a strong correlation to DV200 or RIN scores but do see robust performance on a variety of samples. We do recommend using a serial section to assess tissue quality prior to running the assay. Details for this can be found in the Xenium Tissue Preparation Guides.
Products: Xenium In Situ Gene Expression